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Citations 9. Supporting Information. Cited By. This article is cited by 9 publications.


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Microfluidics Synthesis of Gene Silencing Cubosomes. ACS Nano , 12 9 , DOI: Maryam Rahmati, Masoud Mozafari. Nano-immunoengineering: Opportunities and challenges. Current Opinion in Biomedical Engineering , 10 , Effects of a cationic surfactant incorporation in phytantriol bulk cubic phases and dispersions loaded with the anticancer drug 5-fluorouracil.

Journal of Molecular Liquids , , Hanna M. Barriga, Margaret N. Hence, Hc cell wall melanin protects the fungus from a myriad of insults and the polymeric nature of the pigment enhances its structural strength. Moreover, yeast melanization appears to play important roles in virulence and pathogenicity. The fungal cell wall is fundamentally the structure that interacts with environmental and host milieus. A current model for the Hc cell wall is presented on the Figure 2.

It provides structural support, varying from flexible to a rigid structure, and protects the cell against environmental stressors and host anti-microbial effectors mechanisms. Many fungal antigens are conserved among phylogenetically related species and many that are associated with virulence can be found on their cell walls.

Hence, common targets could be used to induce protection against different fungal species described Casadevall and Pirofski, Although approaches to developing protective responses vary from vaccination with cells or recombinant antigens to passive protection with mAbs, coordinating knowledge across the fungal pathogens may lead to new, more effective means for combating potentially lethal mycoses.

In this survey of Hc surface structures, we demonstrate the function of diverse antigens in regulating Hc biology and discuss the current knowledge base from which we can build upon in future investigations. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Ajello, L. Coccidioidomycosis and histoplasmosis. A review of their epidemiology and geographical distribution.

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Akiyama, T. A cell wall-bound beta-glucosidase from germinated rice: purification and properties. Phytochemistry 48, 49— Albuquerque, P. Vesicular transport in Histoplasma capsulatum : an effective mechanism for trans-cell wall transfer of proteins and lipids in ascomycetes. Allendoerfer, R. Modulation of immune responses in murine pulmonary histoplasmosis. Cellular immune responses to recombinant heat shock protein 70 from Histoplasma capsulatum. Pubmed Abstract Pubmed Full Text.


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  4. Alteras, I. First Romanian isolation of Histoplasma capsulatum from the soil. Anjos, A. Role of Paracoccidioides brasiliensis cell wall fraction containing beta-glucan in tumor necrosis factor-alpha production by human monocytes: correlation with fungicidal activity.

    Aramaki, Y. Liposomes as immunomodulator — inhibitory effect of liposomes on NO production from macrophages.

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    Azuma, I. Chemical and immunological properties of galactomannans obtained from Histoplasma duboisii, Histoplasma capsulatum, Paracoccidioides brasiliensis and Blastomyces dermatitidis. Barr, K. Carbohydrate structures of three novel phosphoinositol-containing sphingolipids from the yeast Histoplasma capsulatum. Biochemistry 23, — Occurrence of novel antigenic phosphoinositol-containing sphingolipids in the pathogenic yeast Histoplasma capsulatum.

    Barreto-Bergter, E. Structure and biological functions of fungal cerebrosides. Berliner, M. Histoplasma capsulatum : vital staining for the differentiation of the albino and brown phenotypes in vitro. Sabouraudia 11, — Bernard, M.

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    Aspergillus fumigatus cell wall: composition and biosynthesis. Bilozur, M. Identification and characterization of heparan sulfate-binding proteins from human lung carcinoma cells. Bittencourt, V.

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    An alpha-glucan of Pseudallescheria boydii is involved in fungal phagocytosis and Toll-like receptor activation. Bohse, M. Surface localization of the Yps3p protein of Histoplasma capsulatum. Cell 4, — Expression and interstrain variability of the YPS3 gene of Histoplasma capsulatum.

    Cell 6, — CrossRef Full Text. Borelli, D. Prevalence of systemic mycosis in Latin America. Mycoses Scient. Bradsher, R. Histoplasmosis and blastomycosis. Bromuro, C. Beta-glucan-CRM conjugates as candidates antifungal vaccines. Vaccine 28, — Brown, G. Dectin a signalling non-TLR pattern-recognition receptor. Bulawa, C. Attenuated virulence of chitin-deficient mutants of Candida albicans. Cambi, A. Cano, M. The epidemiology of histoplasmosis: a review.

    Caruso, M. Heat shock 70 gene is differentially expressed in Histoplasma capsulatum strains with different levels of thermotolerance and pathogenicity.

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    Casadevall, A. Vesicular transport across the fungal cell wall. Trends Microbiol. Antibody-mediated protection through cross-reactivity introduces a fungal heresy into immunological dogma. Cash, H.

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    Refolding, purification, and characterization of human and murine RegIII proteins expressed in Escherichia coli. Protein Expr. Couto, M. Inhibition of intracellular Histoplasma capsulatum replication by murine macrophages that produce human defensin. Cox, R. Cell wall composition of two strains of Blastomyces dermatitidis exhibiting differences in virulence for mice. Csillag, A. Da Silva, A.