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Read PDF Ciba Foundation Symposium 196 - Growth Factors as Drugs for Neurological and Sensory Disorders

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There are extensive interconnections to other parts of the brain, such as the hippocampus, thalamus, hypothalamus, and frontal lobe, suggesting effects on other biologic functions. The actual olfactory receptor sites are structurally similar to the taste receptors of the mouth and the photoreceptors of the retina.

The receptor is a single polypeptide chain consisting of approximately amino acids, which folds back and forth onto itself to traverse the cellular membrane seven times. The outer end of the polypeptide contains an amine group N-terminal and the cytosolic end contains a carboxyl group C-terminal.

The transmembranous portions determine the receptor shape and characteristics of the binding site. Smelling is an extremely sensitive mechanism of detecting xenobiotics. Olfactory receptors can detect the presence of a few molecules of certain xenobiotics with a sensitivity that is superior to some of the most sophisticated laboratory detection instruments.

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How Sensory Processing Disorder Can Change

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Because of the lack of standardized diagnostic techniques and normal parameters, such adverse effects may be overlooked and dismissed by healthcare providers, despite significant patient distress and dysfunction. This is particularly true for disorders of olfaction and gustation. This chapter reviews the anatomy and physiology of these senses; describes the effects of xenobiotics on these senses and examines the significant diagnostic information these senses contribute to identifying the presence of xenobiotics. Understanding the effects of xenobiotics on the senses may allow for early detection, which occasionally can be lifesaving.

Anne L. Calof

Olfactory receptors are bipolar neurons located in the superior nasal turbinates and the adjacent septum. There are 10 to 20 million receptor cells per nasal chamber, and the receptor portion of the cell undergoes continuous renewal from the olfactory epithelium. These olfactory receptor neurons are distinctive in their ability to regenerate.

Within the dura, these bundles form connections with the olfactory bulb from which neural projections then connect to the olfactory cortex. There are extensive interconnections to other parts of the brain, such as the hippocampus, thalamus, hypothalamus, and frontal lobe, suggesting effects on other biologic functions. The actual olfactory receptor sites are structurally similar to the taste receptors of the mouth and the photoreceptors of the retina.

The receptor is a single polypeptide chain consisting of approximately amino acids, which folds back and forth on itself to traverse the cellular membrane seven times. The outer end of the polypeptide contains an amine group N-terminal and the cytosol end contains a carboxyl group C-terminal.

The transmembranous portions determine the receptor shape and characteristics of the binding site.

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Smelling is an extremely sensitive mechanism of detecting xenobiotics. Olfactory receptors can detect the presence of a few molecules of certain xenobiotics with a sensitivity that is superior to some of the most sophisticated laboratory detection instruments. The sense of smell can be extremely useful as a toxicologic warning system. Human olfaction is a variable trait. Forgot Password? What is MyAccess? Otherwise it is hidden from view. Forgot Username? About MyAccess If your institution subscribes to this resource, and you don't have a MyAccess Profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.

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AccessEmergency Medicine. Case Files Collection. Clinical Sports Medicine Collection. Davis AT Collection.